fragile x mental retardation protein is reduced in cerebella of subjects with autism
نویسندگان
چکیده
autism and fragile x syndrome have multiple behavioral phenotypes in common, however there has been little research into the potential role of fragile x mental retardation protein (fmrp) in autism. we sought to measure protein levels of fmrp in the lateral cerebella of subjects with autism and matched controls. we found significantly reduced levels of fmrp (p<0.0063) in subjects with autism. the loss of fmrp expression in subjects with autism may help explain behavioral deficits, presence of seizure, and reduction in gaba receptors in subjects with autism.
منابع مشابه
Fragile X mental retardation protein: from autism to neurodegenerative disease
INTRODUCTION Fragile X mental retardation protein (FMRP) is a RNA binding protein, the absence of which due to silencing of the FMR1 gene causes fragile X syndrome, an X-linked neurodevelopmental disorder (Bassell and Warren, 2008; Bhakar et al., 2012; Santoro et al., 2012). FMRP regulates the transport, stability and translation of its mRNA targets. Loss of FMRP alters translational control an...
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عنوان ژورنال:
iranian journal of psychiatry and behavioral sciencesجلد ۴، شماره ۲، صفحات ۵۶-۵۷
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